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Rohan Paul· @rohanpaul_ai · X·· 1 天前精选AI 评分75
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Anthropic 科学博客介绍,Claude 在其 Claude Science 环境中以智能体方式自主完成整套蛋白质设计流程,针对蝎毒神经毒素设计结合蛋白。

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Anthropic 科学博客披露 Claude 作为智能体自主完成蛋白质设计流程,并给出两处实验室验证的分子数量。

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Claude did the protein scientist’s job and came back with 17 molecules that grip scorpion neurotoxins.

Claude, running as an agent inside Anthropic’s Claude Science setup, ran the whole protein-design campaign itself:

it picked which patch of each scorpion toxin to attack, drove 12 protein-design programs, set its own scoring cutoffs, and chose 180 molecules out of the 318,484 it generated for physical synthesis, and 17 of the 211 designs tested bound their toxin at Adaptyv Bio and Twist Bioscience.

Citrini Research, a finance firm with no lab and no protein expertise, asked for this work, and Claude designed proteins that two labs confirmed latch onto scorpion venom toxins.

Scorpion stings kill more than 3,250 people a year, so the prize is real, if this method works. However, Anthropic is not calling this an antivenom, because the test that would justify the word has not been run yet.

引用Anthropic@AnthropicAI
New on our Science Blog: designing protein binders against scorpion neurotoxins. Scorpions sting about 1.2m people every year, and antivenoms are often costly or in short supply. Claude has made an early step toward finding new treatments. https://www.anthropic.com/research/claude-scorpion-toxin-binder-design
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来源:Rohan Paul · x.com